ELSI
This research proposes a new methodology for controlling the oscillation period by modifying amino acids in DNA molecules. This synthetic biology approach aims to modify metabolic rhythms based on the circadian clock, and by designing artificial concentration rhythms, it opens up new possibilities for chemical perturbation in living organisms. Because this challenge involves intervening in the rhythms of life, careful consideration is required from ethical, legal, and social perspectives.
○Ethical Issues
Intervention in the Time Control of Life
This technology designs artificial concentration rhythms similar to biological clocks and could be seen as intervention in the fundamental rhythms of life. This raises ethical debates about the "naturalness of life" and the "limits of artificial manipulation."
Definition of Self-Maintaining Life
The DNA oscillation addressed in this research approaches a self-maintaining system. It confronts the scientific and ethical question of "What is life?" In particular, the emergence of artificial entities with self-maintaining rhythms may lead to a re-examination of the definition of life.
○Legal Issues
Intellectual Property and Technology Sharing
The design of DNA oscillators through amino acid modification is a highly original technology that requires organization of patents and licenses. At the same time, the trend of open science in the field of synthetic biology cannot be ignored, and a balance between technology disclosure and monopoly is required.
Regulatory Compliance in Biological Applications
If this technology is applied to medical or health promotion in the future, it will be necessary to ensure consistency with pharmaceutical laws and biosafety-related legal systems. In particular, since the control of concentration rhythms in the body may affect drug efficacy and metabolism, the establishment of a legal framework is required.
○Social Issues
Understanding and Acceptance of Technology
The new concept of DNA oscillators may be unfamiliar to the general public, potentially leading to misunderstandings and anxieties. It is essential to ensure transparency in technology and promote social understanding through scientific communication.
Need for Education and Ethical Research
The technology of synthetic biology requires a space for ethical discussions at the stages of education and research and development. The theme of controlling the timing of life is an important question for the younger generation as well, and the development and dissemination of educational content is essential.